Low Back Ache Treatment with Botulinum Neurotoxin Type A

Neurologic uses of botulinum neurotoxin type A

This article reviews the current and most neurologic uses of botulinum neurotoxin type A (BoNT-A), beginning with relevant historical data, neurochemical mechanism at the neuromuscular junction. Current commercial preparations of BoNT-A are reviewed, as are immunologic issues relating to secondary failure of BoNT-A therapy. Clinical uses are summarized with an emphasis on controlled clinical tr...

Botulinum Neurotoxin Type A in Neurology: Update

This paper reviews the current and most neurological (central nervous system, CNS) uses of the botulinum neurotoxin type A. The effect of these toxins at neuromuscular junction lends themselves to neurological diseases of muscle overactivity, particularly abnormalities of muscle control. There are seven serotypes of the toxin, each with a specific activity at the molecular level. Currently, ser...

Purification of Clostridium botulinum type A neurotoxin.

Protein Domain Analysis of C. botulinum Type A Neurotoxin and Its Relationship with Other Botulinum Serotypes

Botulinum neurotoxins (BoNTs) are highly potent poisons produced by seven serotypes of Clostridium botulinum. The mechanism of neurotoxin action is a multistep process which leads to the cleavage of one of three different SNARE proteins essential for synaptic vesicle fusion and transmission of the nerve signals to muscles: synaptobrevin, syntaxin, or SNAP-25. In order to understand the precise ...

efficacy of botulinum toxin type a for treating chronic low back pain

conclusions bont-a improves clbp with a low incidence of side effects and can be used as a therapeutic tool in the management of these patients. results after 4 weeks, 76% of patients in the bont-a group reported pain relief compared to 20% in the saline group (p < 0. 005). additionally, greater pain relief was experienced by patients in the bont-a group at 8 weeks (64% vs. 12%; p < 0. 001). by...